Summary: High-intensity alcohol drinking during binge episodes contributes to the socioeconomic burden created by alcohol use disorders (AUDs), and nociceptin receptor (NOP) antagonists have emerged as a promising intervention.To CURL FINISH SPRAY better understand the contribution of the NOP system to binge drinking, we found that nociceptin-conta

Kai-Uwe Kern,1 Janice England,2 Andrea Roth-Daniek,3 Till Wagner3 1Institute for Pain Medicine/Pain Practice, Wiesbaden, Germany; 2Pain Medicine and Anaesthesia, The Christie National Health Service Foundation Trust, Manchester, UK; 3Pain Therapy and Palliative Care Department, Medizinisches Zentrum Städteregion Aachen, Aachen, Germany Abstrac

An extended nonlinear disturbance observer (ENDOB)-based fuzzy sliding mode control approach is proposed for single-input and single-output systems with matched and mismatched uncertainties/disturbances, and it is extended to the general $n$ th order systems.By integrating the mismatched disturbance estimation and its derivative into the sliding mo

Abstract Severe burn injury is often accompanied by intestinal barrier dysfunction, which is closely associated with post-burn shock, BAGS bacterial translocation, systemic inflammatory response syndrome, hypercatabolism, sepsis, multiple organ dysfunction syndrome, and other complications.The intestinal epithelium forms a physical barrier that sep

When environmental processes cut across socioeconomic boundaries, traditional top-down government approaches struggle to effectively manage and conserve ecosystems.In such cases, governance arrangements that foster multiactor collaboration are needed.The effectiveness of such arrangements, however, depends on how well any ecological interdependenci